{"id":5013,"date":"2024-09-06T15:54:55","date_gmt":"2024-09-06T15:54:55","guid":{"rendered":"https:\/\/uni-vite.com\/immunoshield\/?p=5013"},"modified":"2024-09-09T10:15:47","modified_gmt":"2024-09-09T10:15:47","slug":"superbugs-threaten-us-all-beta-glucans-boost-immune-system","status":"publish","type":"post","link":"https:\/\/uni-vite.com\/immunoshield\/superbugs-threaten-us-all-beta-glucans-boost-immune-system\/","title":{"rendered":"The superbugs that threaten us all"},"content":{"rendered":"
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What can you do against this silent pandemic?<\/strong><\/h2>\n

The Sunday Times<\/em> front page on September 1st<\/sup>\u00a02024 led with the rise of anti-microbial resistance \u2013 which they described as a \u201csilent pandemic<\/em>\u201d.<\/p>\n

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\u201cFor decades doctors have warned of a dystopian future in which antibiotics are rendered useless ...\u201d<\/p>\n<\/blockquote>\n

... by bacteria that have evolved resistance to all known drugs.<\/p>\n

The Sunday Times lamented that in some hospitals that future has come.<\/p>\n

We shouldn\u2019t really be surprised, because in 2014 the World Health Organization (WHO) had already warned that Anti-Microbial Resistance (AMR) is one of the most serious global public health threats in this century.<\/p>\n

Ref. Antimicrobial resistance: a global multifaceted phenomenon - PMC (nih.gov)<\/a>.<\/h6>\n

This is echoed in Health Science Reports, <\/em>headed: \"Superbugs or multidrug resistant microbes: A new threat to society\"<\/em><\/strong>.<\/em><\/p>\n

Ref. Superbugs or multidrug resistant microbes: A new threat to the society - PMC (nih.gov)<\/a><\/h6>\n

So, what can you do as the season approaches where bacterial and viral infections rise \u2013 and immune-supporting vitamin D3 levels from sunlight decline?<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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 <\/p>\n

Colin Rose is a Senior Associate Member of the Royal Society of Medicine, and Fellow of the Royal Society of Arts. He is the Founder and Director of Research and Innovation of Uni-Vite Healthcare and author of a recent <\/em><\/span>book: Delay Ageing: Healthy to 100<\/strong>, where he reveals how to slow ageing and, therefore, help prevent later-life illness.<\/em><\/span><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>

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How AMR (anti-microbial resistance) occurs<\/h3>\n

The more antibiotics are prescribed \u2013 quite often for issues where they don\u2019t work like viral infections \u2013 the more likely bugs evolve resistance. This is made worse because antibiotics are over-used in animal rearing.<\/p>\n

\"Doctor<\/p>\n

The risk is further compounded because we now know that the bugs themselves can swap genes from one strain to another \u2013 fuelling faster and faster resistance.<\/p>\n

The place where there are the most bacteria? Hospitals!<\/p>\n

Where, by definition, multiple infections are treated. Meaning a simple operation like removing tonsils or a hip replacement could ultimately be life-threatening.<\/p>\n

A Lancet<\/em> report in 2022 estimated that almost 5 million deaths worldwide in 2019 were already due to AMR and this could rise to 50 million by 2050.<\/p>\n<\/div>\n<\/div><\/div>

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Your best defence is a strong immune system<\/h3>\n

A strong immune system helps protect you, and your family, not just against bacteria, but against viral and fungal infections and mutated cells \u2013 cancer.<\/p>\n

\"Energetic<\/p>\n

The plan we have developed over the last 20 years contains the foods and lifestyle that support a strong immune system \u2013 as well as extending your health span! \u00a0The Delay Ageing Healthy Eating Food Plan| NutriShield<\/a>. Note the highlighting of mushrooms and especially shiitake.<\/p>\n

But there is more you can do.<\/p>\n<\/div>\n<\/div><\/div>

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How beta glucans improve immune response<\/strong><\/h3>\n

Beta-glucans, specifically the 1-3, 1-6 type, have been extensively studied for their immune-modulating properties.<\/p>\n

1. Immune System Enhancement<\/strong><\/h4>\n

Beta-glucans are known to enhance the immune system by activating various immune cells such as macrophages, dendritic cells, natural killer cells and T-cells. This activation helps the body to better defend against all classes of pathogens \u2013 as well as mutated cells.<\/p>\n

\"White
Immune system white blood cells<\/figcaption><\/figure>\n

2. Mechanism of Action<\/strong><\/h4>\n

The beta glucan 1-3, 1-6 polysaccharide compounds interact with specific receptors on immune cells, such as Dectin-1<\/em>, which leads to a strong and beneficial cascade of immune responses.<\/p>\n

3. Clinical Trials and Safety<\/strong><\/h4>\n

Clinical trials have shown that oral intake of beta glucans \u2013 and specifically the WellmuneTM<\/sup> in ImmunoShield \u2013 is safe and effective in strengthening the immune system.<\/p>\n

\"Wellmune<\/p>\n

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4. Health Benefits<\/strong><\/h4>\n

Beyond improved immune support, 1-3, 1-6 beta-glucans have been found to have other health benefits, including anti-inflammatory, antimicrobial, hepatoprotective (liver protective), and wound healing effects.<\/p>\n

5. Sources and structure of beta glucans<\/strong><\/h4>\n

The effectiveness of beta glucans can vary depending on their source and structure. Beta glucans derived from yeast (Saccharomyces cerevisiae<\/em>) are particularly important for their potent immune-activating properties.<\/p>\n

Ref: Beta Glucan Research<\/a>\u00a0<\/a>:\u00a0Immune-modulatory effects of dietary Yeast Beta-1,3\/1,6-D-glucan<\/a><\/h6>\n<\/div>\n<\/div><\/div>
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Beta sitosterol is an immune modulator<\/strong><\/h3>\n

Another immune modulator is a plant sterol called beta sitosterol<\/strong> \u2013 food sources of which include olive oil, avocado and nuts like walnuts and almonds.<\/p>\n

\"Walnuts\"
Walnuts are high in beta sitosterol<\/figcaption><\/figure>\n

Research suggests that beta sitosterol\u00a0also enhances the activity of immune cells, such as natural killer cells and macrophages. These play vital roles in identifying and eliminating pathogens and abnormal cells in the body. By boosting immune cell function, beta sitosterol can help promote a stronger immune response.<\/p>\n

Ref. Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer - PMC (nih.gov)<\/a><\/h6>\n

The supplement ImmunoShield is unique in combining Wellmune 1-3, 1-6 beta glucans with beta sitosterol (and zinc).<\/p>\n

You can read more detail below \u2013 or see more on the Immunoshield website now: ImmunoShield - Beta Glucans Immune Booster Supplement | Uni-Vite Healthcare<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div>

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Scientists started studying beta glucans over a hundred years ago<\/strong><\/h3>\n

The beta glucans that improve the immune system are different in structure from the oat beta glucans that, in dosages of over 3 grams, can lower cholesterol levels. Both types need to come from supplements or your diet.<\/p>\n

\"Beta<\/p>\n

Studies, starting as early as the 1920s, have shown that the 1-3,1-6 beta glucans we review here are effective in doses of 250 mg a day. They trigger a cascade of events that help regulate the immune system, making it more efficient.<\/p>\n

1. Beta glucans stimulate the activity of macrophages,<\/em>\u00a0which are immune cells that ingest and demolish invading\u00a0pathogens<\/em>\u00a0and stimulate other immune cells to attack invaders.<\/p>\n

2. Macrophages also release cytokines,<\/em> natural chemicals that enable immune cells to communicate with one another.<\/p>\n

3. In addition, beta glucans stimulate the good white blood cells (lymphocytes)<\/em>\u00a0that bind to tumours or viruses, and release chemicals to destroy them.<\/p>\n

The most studied beta 1-3, 1-6 glucan supplements are derived from the cell wall of baker\u2019s yeast. WellmuneTM<\/sup>\u00a0 has by far the most research behind it. It is a purified extract which will not contain enough yeast protein to cause any allergic reactions.<\/p>\n<\/div>\n<\/div><\/div>

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Beta glucans and the immune system<\/strong><\/h3>\n

Flu viruses, as an example, bind to and stop a part of the immune system called \u2018complement\u2019. <\/em>Complement is needed to prevent viruses from taking hold. Beta 1-3, 1-6 glucans actively inhibit<\/strong> this binding effect, and so ensure activation of the immune system in response to the virus.<\/p>\n

Infection from, say, a flu virus takes about 48 hours after the virus has entered the body. If the immune system is activated, it will prevent the virus from replicating, so flu is less likely to take hold.<\/p>\n

Research on WellmuneTM<\/sup> at the Mayo Clinic and Universities of Louisville, Brown and Berlin, has shown that constant stimulation of cell receptors is necessary to keep immune cells fully functional. It does not, however, lead to an over-stimulation of the immune system \u2013 which can manifest as a dangerous cytokine storm \u2013 and which has been mentioned as a potential concern with echinacea.<\/p>\n

WellmuneTM <\/sup>\u00a0has been evaluated across a wide range of populations to show significant alleviation of Upper Respiratory Tract infections, allergies and age\u2010related immuno\u2010suppression.<\/p>\n

Ref. \u03b2\u20101,3\/1,6\u2010Glucans and Immunity: State of the Art and Future Directions - PMC (nih.gov)<\/a><\/h6>\n

A natural question is \u2013 could 1-3, 1-6 beta glucans, which support the immune system, therefore help identify and fight mutated cells and thus support cancer treatment?<\/p>\n

This has been the subject of several studies \u2013 especially in Japan, where they are approved as \"adjunct therapy\" \u2013 support to conventional treatments.<\/p>\n<\/div>\n<\/div><\/div>

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Beta glucans and cancer<\/strong><\/h3>\n

Beta glucans may indeed have a role in fighting cancer. We know beta glucans can mobilise Natural Killer cells (NK cells) during the early stage of cancer, which are crucial to inhibiting cancer growth.<\/p>\n

Other research indicates beta glucans may interfere with a tumour\u2019s blood supply (a process called anti-angiogenesis). This could help reduce cancer cell proliferation and stifle metastasis (mutation and spread).<\/p>\n

Mushroom-derived beta glucans and yeast-derived beta glucans<\/strong><\/h4>\n

Most of the studies on the anti-tumour properties of 1-3, 1-6 beta glucan, however, have been conducted in Japan with beta glucans derived from various types of mushrooms. \u00a0And using dosages between 750-1500 mg per day, taken between meals 500 mg at a time. These doses are substantially higher than the daily preventative use against viral and bacterial pathogens of 250mg per day.<\/p>\n

It\u2019s important to note that, while 1-3,1-6 beta glucans from yeast and mushrooms (especially shiitake mushrooms) are structurally similar, there are differences.<\/p>\n

\"Shiitake
Shiitake mushrooms<\/figcaption><\/figure>\n

Mushroom-derived beta glucans contain higher amounts of a compound called Lentinan <\/em>and researchers at Teikyo University's Biotechnology Research Center Japan, showed that lentinan helps suppress the formation and development of tumours.<\/p>\n

In another Japanese study, mice with tumours that received beta glucans, including lentinan, experienced a rapid decrease in the number of tumour cells, as well as a notable increase in neutrophil numbers in solid tumours. Neutrophils are white blood cell that help destroy rogue cells by secreting chemicals to break them down.<\/p>\n

Ref. Potential benefit of \u03b2-glucans as adjuvant therapy in immuno-oncology: a review - PMC (nih.gov)<\/a><\/h6>\n

However, it\u2019s also true that the molecular structure of beta glucans derived from mushrooms is varied and often inconsistent, depending on how they are grown. Whereas beta glucans from yeast use a standardised process, ensuring consistency.<\/p>\n

As regards safety, one key report concluded:<\/p>\n

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\u00a0\u201cCompared with conventional medical therapies, beta glucans are an affordable and safe option for preventing and healing cancer while posing no adverse health reactions.\u201d<\/em><\/p>\n<\/blockquote>\n

Ref. \u03b2-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties - ScienceDirect<\/a><\/h6>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Summary<\/h3>\n

Your immune system loses strength as you get older \u2013 which is why recovery from infections and flu usually takes longer \u2013 and cancer risk rises.<\/p>\n

For this reason \u2013 and in the light of increased Anti-Microbial Resistance \u2013 a supplement including 1-3,1-6 beta glucans could help. And now, as Autumn and Winter approach, is the time to get it.<\/p>\n

ImmunoShield not only contains WellmuneTM <\/sup> but also beta sitosterol and zinc. See ImmunoShield - Beta Glucans Immune Booster Supplement | Uni-Vite Healthcare<\/a><\/p>\n<\/div>\n<\/div><\/div>

<\/span>Buy ImmunoShield Now<\/a><\/div><\/div>
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The NHS also recommends Vitamin D3 supplementation in winter \u2013 and you can top up supplies here: Vitamin D3 | High-strength Natural Vitamin D | Nutrishield (nutrishield.com)<\/a><\/p>\n<\/div>\n<\/div><\/div>

<\/span>Buy Vitamin D3 Now<\/a><\/div><\/div>
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Buy all Uni-Vite's health supplements securely online here.<\/p>\n

\"Uni-Vite<\/p>\n

 <\/p>\n<\/div>\n<\/div><\/div>

<\/span>Buy Uni-Vite Health Supplements Now<\/a><\/div><\/div>
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Register now for a free regular e-newsletter on the latest in nutrition and health research.\"CTA<\/a><\/h4>\n
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Dr Paul Clayton designed NutriShield as a comprehensive health\"button-2\"<\/a> supplement with OPTIMUM levels of essential nutrients including a full range of vitamins and minerals, plus grapeseed extract, Omega 3, curcumin and green tea. Click on the button for more details.<\/p>\n

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 <\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

What can you do against this silent pandemic? The Sunday Times front page on September 1st\u00a02024 led with the rise of anti-microbial resistance \u2013 which they described as a \u201csilent pandemic\u201d. \u201cFor decades doctors have warned of a dystopian future in which antibiotics are rendered useless …\u201d … by bacteria that have evolved resistance to … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":5024,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-5013","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-immune-system"],"yoast_head":"\r\nThe superbugs that threaten us all - ImmunoShield<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/uni-vite.com\/immunoshield\/superbugs-threaten-us-all-beta-glucans-boost-immune-system\/\" \/>\r\n<meta property=\"og:locale\" content=\"en_GB\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"The superbugs that threaten us all - ImmunoShield\" \/>\r\n<meta property=\"og:description\" content=\"What can you do against this silent pandemic? The Sunday Times front page on September 1st\u00a02024 led with the rise of anti-microbial resistance \u2013 which they described as a \u201csilent pandemic\u201d. \u201cFor decades doctors have warned of a dystopian future in which antibiotics are rendered useless ...\u201d ... by bacteria that have evolved resistance to ... 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